蛋白质设计中的能量估算。
Energy estimation in protein design.
作者信息
Mendes Joaquim, Guerois Raphael, Serrano Luis
机构信息
European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.
出版信息
Curr Opin Struct Biol. 2002 Aug;12(4):441-6. doi: 10.1016/s0959-440x(02)00345-7.
Abstract
The progress achieved by several groups in the field of computational protein design shows that successful design methods include two major features: efficient algorithms to deal with the combinatorial exploration of sequence space and optimal energy functions to rank sequences according to their fitness for the given fold.
摘要
计算蛋白质设计领域的几个团队所取得的进展表明，成功的设计方法包括两个主要特征：用于处理序列空间组合探索的高效算法，以及根据序列对给定折叠的适合度对其进行排序的最优能量函数。
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