Bushell Martin, Sarnow Peter
Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA.
J Cell Biol. 2002 Aug 5;158(3):395-9. doi: 10.1083/jcb.200205044.
As invading viruses do not harbor functional ribosomes in their virions, successful amplification of the viral genomes requires that viral mRNAs compete with cellular mRNAs for the host cell translation apparatus. Several RNA viruses have evolved remarkable strategies to recruit the host translation initiation factors required for the first steps in translation initiation by host cell mRNAs. This review describes the ways that three families of RNA viruses effectively usurp limiting translation initiation factors from the host.
由于入侵的病毒在其病毒粒子中不含有功能性核糖体，因此病毒基因组的成功扩增要求病毒mRNA与细胞mRNA竞争宿主细胞的翻译装置。几种RNA病毒已经进化出非凡的策略，以募集宿主细胞mRNA翻译起始第一步所需的宿主翻译起始因子。本综述描述了三类RNA病毒有效夺取宿主有限翻译起始因子的方式。
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