Nakatsuka Mikiya, Takata Masayo, Tada Katsuhiko, Asagiri Kazuo, Habara Toshihiro, Noguchi Soichi, Kudo Takafumi
Department of Obstetrics and Gynecology, Okayama University Medical School, Japan.
J Ultrasound Med. 2002 Aug;21(8):831-6. doi: 10.7863/jum.2002.21.8.831.
To determine the effects of long-term transdermal administration (range, 4-30 days; mean +/- SD, 11.1+/-7.2 days) of isosorbide dinitrate, a nitric oxide donor, in preeclamptic women.
We studied uterine and fetoplacental circulation of 12 preeclamptic women with oligohydramnios and an elevated pulsatility index in the uterine arteries.
Transdermal isosorbide dinitrate significantly suppressed the blood pressure of patients. Pulsed Doppler ultrasonography revealed that the average pulsatility index in the uterine arteries was significantly reduced by treatment with isosorbide dinitrate (P < .003). The average pulsatility index in the umbilical artery was also significantly reduced (P < .004). Furthermore, the size of the amniotic fluid pocket increased approximately 4-fold by treatment with isosorbide dinitrate.
Long-term transdermal administration of isosorbide dinitrate improves fetoplacental circulation and may be effective therapy for avoiding maternal hypertension and oligohydramnios in some preeclamptic women.
确定一氧化氮供体硝酸异山梨酯长期经皮给药（范围为4 - 30天；平均±标准差，11.1±7.2天）对先兆子痫妇女的影响。
我们研究了12例羊水过少且子宫动脉搏动指数升高的先兆子痫妇女的子宫和胎儿 - 胎盘循环。
经皮给予硝酸异山梨酯可显著降低患者血压。脉冲多普勒超声检查显示，硝酸异山梨酯治疗可使子宫动脉的平均搏动指数显著降低（P < 0.003）。脐动脉的平均搏动指数也显著降低（P < 0.004）。此外，硝酸异山梨酯治疗使羊水池大小增加了约4倍。
硝酸异山梨酯长期经皮给药可改善胎儿 - 胎盘循环，可能是避免某些先兆子痫妇女发生母体高血压和羊水过少的有效疗法。
