Nakatsuka M, Tada K, Kimura Y, Asagiri K, Kamada Y, Takata M, Nakata T, Inoue N, Kudo T
Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama City, Okayama, Japan.
Gynecol Obstet Invest. 1999;47(1):13-9. doi: 10.1159/000010055.
Isosorbide dinitrate (ISDN), a nitric oxide donor, was applied transdermally for 4-16 days to 4 preeclamptic women with oligohydramnios, intrauterine fetal growth retardation (IUGR), and elevated resistance of blood flow in the uterine arteries. Pulsed Doppler ultrasonography revealed immediate and drastic improvement of pulsatility index (PI) of uterine arteries following treatment with ISDN. The average PI in uterine arteries of the 4 patients was reduced to approximately 67% of that of the untreated state. In 2 patients the amniotic fluid gradually increased over a few days which suggested improvement of fetoplacental circulation during administration of ISDN. This study suggests that long-term transdermal ISDN is an effective therapy, at least in a portion of preeclamptic women, to avoid maternal hypertension, fetal distress, oligohydramnios, and IUGR, and consequentially to prolong the gestational period.
硝酸异山梨酯（ISDN），一种一氧化氮供体，经皮应用于4例患有羊水过少、胎儿宫内生长受限（IUGR）以及子宫动脉血流阻力升高的先兆子痫妇女，持续4 - 16天。脉冲多普勒超声检查显示，经ISDN治疗后子宫动脉搏动指数（PI）立即且显著改善。4例患者子宫动脉的平均PI降至未治疗状态时的约67%。2例患者的羊水在数天内逐渐增加，这表明在ISDN给药期间胎儿 - 胎盘循环有所改善。本研究表明，长期经皮应用ISDN是一种有效的治疗方法，至少对部分先兆子痫妇女而言，可避免母体高血压、胎儿窘迫、羊水过少和IUGR，从而延长妊娠期。
