Birnbaum Warren, Hodgson T A, Reichart P A, Sherson W, Nittayananta W, Axell T E
Guy's, King's and St Thomas' Dental Institute, London, UK.
Oral Dis. 2002;8 Suppl 2:110-4. doi: 10.1034/j.1601-0825.2002.00021.x.
The oral manifestations of HIV infection have been considered to be of value in assessing disease progression in the developed world. However, the potential use of oral lesions as prognostic markers in resource-poor countries has yet to be fully investigated. There is reasonably compelling evidence in the developed world for an association between oral lesions and viral load. However, the true nature of this association is less clear and there are few data available from the developing world. With the introduction of HAART, a change in prevalence of the oral manifestations of HIV infection has been observed, including regression of oral candidiasis, Kaposi's sarcoma and oral hairy leukoplakia. However, oral condylomata and herpes simplex virus infection appear to persist with HMRT therapy. Further research in partnership with resource-poor countries is required to document disease progression and the associated oral lesions in both adults and children.
在发达国家，HIV感染的口腔表现被认为对评估疾病进展具有重要价值。然而，在资源匮乏的国家，口腔病变作为预后标志物的潜在用途尚未得到充分研究。在发达国家，有相当有说服力的证据表明口腔病变与病毒载量之间存在关联。然而，这种关联的真实性质尚不清楚，而且发展中国家的相关数据很少。随着高效抗逆转录病毒疗法（HAART）的引入，人们观察到HIV感染的口腔表现患病率发生了变化，包括口腔念珠菌病、卡波西肉瘤和口腔毛状白斑的消退。然而，口腔尖锐湿疣和单纯疱疹病毒感染在高效抗逆转录病毒疗法治疗后似乎仍然存在。需要与资源匮乏的国家合作进行进一步研究，以记录成人和儿童的疾病进展及相关口腔病变。
