CD44v3与乙酰肝素酶的共表达与人结肠癌转移相关。

Co-expression of CD44v3 and heparanase is correlated with metastasis of human colon cancer.

作者信息

Kuniyasu Hiroki, Chihara Yoshitomo, Kubozoe Tadahiko, Takahashi Tadateru

机构信息

Department of Oncological Pathology, Nara Medical University Cancer Center, Shijo-cho, Kashihara, Japan.

出版信息

Int J Mol Med. 2002 Sep;10(3):333-7.

PMID:12165810

Abstract

Heparanase is an enzyme that degrades extracellular glycoprotein to release heparan sulfate molecules. CD44 variant exon 3 (CD44v3), a receptor for heparan sulfate, generates intracellular signals for cell migration. Production of CD44v3 and expression of heparanase were detected by immunohistochemistry and in situ hybridization, respectively. In 145 cases of colon cancer, heparanase mRNA and CD44v3 protein were detected in 46% and 43%, respectively. Co-expression of heparanase and CD44v3 was found in cases of 12% of Dukes' B, 32% of Dukes' C, and 57% of Dukes' D cases. Survival analysis found a significantly poorer prognosis in patients showing concurrent expression of heparanase and CD44v3 than in patients not showing both (p<0.0001). Concurrent expression of heparanase and CD44v3 might be a mechanism of cancer invasion and metastasis in colon cancer.

摘要

乙酰肝素酶是一种可降解细胞外糖蛋白以释放硫酸乙酰肝素分子的酶。硫酸乙酰肝素的受体CD44变异外显子3（CD44v3）可产生细胞迁移的细胞内信号。分别通过免疫组织化学和原位杂交检测CD44v3的产生及乙酰肝素酶的表达。在145例结肠癌病例中，分别有46%和43%检测到乙酰肝素酶mRNA和CD44v3蛋白。在12%的杜克B期、32%的杜克C期和57%的杜克D期病例中发现乙酰肝素酶和CD44v3共表达。生存分析发现，与未同时表达乙酰肝素酶和CD44v3的患者相比，同时表达这两者的患者预后明显更差（p<0.0001）。乙酰肝素酶和CD44v3的同时表达可能是结肠癌侵袭和转移的一种机制。