Guarnieri A, Marazzi F, Giorgi M P, Canepari G, Pino C, Moggia E, Manca A, Ghezzi P M
UU. OO. Nefrologia e Dialisi, A.O. S. Croce e Carle, Cuneo, Italy.
G Ital Nefrol. 2002 Jan-Feb;19(1):79-81.
The treatment of mixed cryoglobulinemia concurrent with HCV infection is still under debate. We report the case of a patient referred to our unit for a membranoproliferative glomerulonephritis associated with HCV infection. A nephrotic syndrome and a slight reduction of glomerular filtration rate were present. We treated him with alpha-interferon for six months and prednisone for two months. We achieved a remission of the nephrotic syndrome without any significant reduction of the viral load. One year after the therapy had been suspended, the nephrotic syndrome relapsed and subsequently responded to a combined treatment with interferon ribavirin and prednisone. HCV-RNA became suddenly and persistently negative.
丙型肝炎病毒（HCV）感染并发混合性冷球蛋白血症的治疗仍存在争议。我们报告了一例因膜增生性肾小球肾炎合并HCV感染转诊至我院的患者。患者存在肾病综合征，肾小球滤过率略有降低。我们用α干扰素治疗他6个月，用泼尼松治疗2个月。我们实现了肾病综合征的缓解，且病毒载量没有显著降低。治疗停止一年后，肾病综合征复发，随后对干扰素-利巴韦林和泼尼松联合治疗有反应。HCV-RNA突然持续转阴。
