Sugiyama Takahide, Oonishi Norio, Onoe Masahiro, Kurita Takashi
Department of Urology, Faculty of Medicine, Kinki University.
Hinyokika Kiyo. 2002 Jun;48(6):343-6.
Prostatic hyperplasia is characterized by major voiding symptoms, and treatment aims principally at improving the quality of life. Nocturnal frequency is a primary symptom that markedly impairs the quality of life. In addition to alpha 1-receptor blockers and antiandrogen agents, herbal medicines and kampo preparations have also been used, but they have not always proved satisfactory. In this study, we investigated the effect of a diuretic kampo preparation (Kanebo Saireito Extract Fine Granules) on urine output, and evaluated the efficacy of Saireito (5.4 g/day, bid) in 12 patients (mean age, about 68) with prostatic hyperplasia who had completed basic therapy but still complained of nocturnal frequency. The following results were obtained. 1) Saireito caused a significant increase of daytime urine output and significantly reduced nocturnal output. 2) It significantly reduced the nocturnal frequency, although that of daytime urination remained unchanged. 3) The drug significantly improved symptoms that existed before treatment. These results suggest that Saireito is effective for nocturia in patients with prostatic hyperplasia.
前列腺增生的特征是主要的排尿症状，治疗主要旨在改善生活质量。夜尿是明显损害生活质量的主要症状。除了α1受体阻滞剂和抗雄激素药物外，草药和汉方药制剂也已被使用，但它们并不总是令人满意。在本研究中，我们研究了一种利尿汉方药制剂（嘉娜宝柴苓汤提取物细颗粒）对尿量的影响，并评估了柴苓汤（5.4克/天，每日两次）对12例（平均年龄约68岁）完成基础治疗但仍有夜尿症状的前列腺增生患者的疗效。获得了以下结果。1）柴苓汤使白天尿量显著增加，夜间尿量显著减少。2）它显著减少了夜尿次数，尽管白天排尿次数保持不变。3）该药物显著改善了治疗前存在的症状。这些结果表明，柴苓汤对前列腺增生患者的夜尿有效。
