[Kampo preparations for prostatic hyperplasia: usefulness of Saireito for nocturia].

Prostatic hyperplasia is characterized by major voiding symptoms, and treatment aims principally at improving the quality of life. Nocturnal frequency is a primary symptom that markedly impairs the quality of life. In addition to alpha 1-receptor blockers and antiandrogen agents, herbal medicines and kampo preparations have also been used, but they have not always proved satisfactory. In this study, we investigated the effect of a diuretic kampo preparation (Kanebo Saireito Extract Fine Granules) on urine output, and evaluated the efficacy of Saireito (5.4 g/day, bid) in 12 patients (mean age, about 68) with prostatic hyperplasia who had completed basic therapy but still complained of nocturnal frequency. The following results were obtained. 1) Saireito caused a significant increase of daytime urine output and significantly reduced nocturnal output. 2) It significantly reduced the nocturnal frequency, although that of daytime urination remained unchanged. 3) The drug significantly improved symptoms that existed before treatment. These results suggest that Saireito is effective for nocturia in patients with prostatic hyperplasia.