Satomoto Maiko, Aoki Hiroshi, Yamada Shigeyuki, Umeda Eiichiro, Adachi Yushi, Higuchi Hideyuki, Watanabe Kazuhiko, Satoh Tetsuo
Medical Corps, 1st Air Wing, Japan Air Self Defense Force, Hamamatsu 432-8551.
Masui. 2002 Jul;51(7):733-6.
The effect of the additional administration of midazolam or flumazenil on bispectral index (BIS) during propofol anesthesia was investigated in 22 scheduled surgical patients. Midazolam 10 or 30 micrograms.kg-1, or flumazenil 6 or 12 micrograms.kg-1 was injected to the patients to evaluate their effect on BIS after achieving steady state of hypnosis more than 1 hr of propofol anesthesia with 5 mg.kg-1.hr-1. The only midazolam 30 micrograms.kg-1 significantly reduced BIS value from 47.8 +/- 8.6 to 36.8 +/- 6.5. The synergistic interaction between midazolam and propofol assessed by BIS might be less clear than that assessed by hypnotic dose of propofol using psychopharmacological investigation.
