Farag Ehab, Chelune Gordon J, Schubert Armin, Mascha Edward J
Department of General Anesthesiology and Outcomes Research, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western University, Cleveland, Ohio 44195, USA.
Anesth Analg. 2006 Sep;103(3):633-40. doi: 10.1213/01.ane.0000228870.48028.b5.
We randomized 74 patients to either a lower Bispectral Index (BIS) regimen (median BIS, 38.9) or a higher BIS regimen (mean BIS, 50.7) during the surgical procedure. Preoperatively and 4-6 wk after surgery, the patients' cognitive status was assessed with a cognitive test battery consisting of processing speed index, working memory index, and verbal memory index. Processing speed index was 113.7 +/- 1.5 (mean +/- se) in the lower BIS group versus 107.9 +/- 1.4 in the higher BIS group (P = 0.006). No difference was observed in the other two test battery components. Somewhat deeper levels of anesthesia were therefore associated with better cognitive function 4-6 wk postoperatively, particularly with respect to the ability to process information.
我们将74例患者随机分为两组，在手术过程中分别采用较低双谱指数（BIS）方案（BIS中位数为38.9）或较高BIS方案（BIS均值为50.7）。术前及术后4 - 6周，使用由处理速度指数、工作记忆指数和言语记忆指数组成的认知测试组合对患者的认知状态进行评估。较低BIS组的处理速度指数为113.7±1.5（均值±标准误），而较高BIS组为107.9±1.4（P = 0.006）。在测试组合的其他两个组成部分中未观察到差异。因此，在术后4 - 6周，稍深的麻醉水平与更好的认知功能相关，特别是在信息处理能力方面。
