双螺旋的GU受体介导tRNA在核糖体中的移动。
GU receptors of double helices mediate tRNA movement in the ribosome.
作者信息
Gagnon Matthieu G, Steinberg Sergey V
机构信息
Département de Biochimie, Université de Montréal, Québec, Canada.
出版信息
RNA. 2002 Jul;8(7):873-7. doi: 10.1017/s135583820202602x.
Abstract
A new RNA structural motif consisting of two double helices closely packed via minor grooves is found in many places in the ribosome structure. The packing requires that a GU base pair in one helix be packed against a Watson-Crick pair in the other helix. Two such motifs mediate the interaction of the P- and E-tRNA with the large ribosomal subunit. Analysis of the particular positions of these two motifs in view of the available data on occupancy of tRNA-binding sites and structural changes in the ribosome during the elongation cycle suggests a distinct role for each motif in tRNA translocation.
摘要
一种由两个通过小沟紧密堆积的双螺旋组成的新型RNA结构基序在核糖体结构的许多位置被发现。这种堆积要求一个螺旋中的GU碱基对与另一个螺旋中的沃森-克里克碱基对堆积在一起。两个这样的基序介导P位和E位tRNA与大核糖体亚基的相互作用。鉴于关于tRNA结合位点占据情况以及延伸循环期间核糖体结构变化的现有数据，对这两个基序的特定位置进行分析表明，每个基序在tRNA易位中具有不同的作用。
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