Architecture et Réactivité de l'ARN, Institut de biologie moléculaire et cellulaire du CNRS, Université de Strasbourg, Strasbourg, France.
Department of Integrated Structural Biology, Institute of Genetics and Molecular and Cellular Biology, INSERM, U964, CNRS, UMR7104, Université de Strasbourg, Illkirch, France.
J Mol Recognit. 2019 Aug;32(8):e2782. doi: 10.1002/jmr.2782. Epub 2019 Apr 29.
Wobble GU pairs (or GoU) occur frequently within double-stranded RNA helices interspersed within the standard G═C and A─U Watson-Crick pairs. However, other types of GoU pairs interacting on their Watson-Crick edges have been observed. The structural and functional roles of such alternative GoU pairs are surprisingly diverse and reflect the various pairings G and U can form by exploiting all the subtleties of their electronic configurations. Here, the structural characteristics of the GoU pairs are updated following the recent crystallographic structures of functional ribosomal complexes and the development in our understanding of ribosomal translation.
摆动 GU 对（或 GoU）在双链 RNA 螺旋中经常出现，这些螺旋散布在标准的 G-C 和 A-U Watson-Crick 对之间。然而，也观察到了其他类型的 GoU 对在其 Watson-Crick 边缘相互作用。这些替代的 GoU 对的结构和功能作用非常多样化，反映了 G 和 U 可以通过利用它们的电子结构的各种细微差别来形成的各种配对。在这里，根据最近的功能性核糖体复合物的晶体结构以及我们对核糖体翻译的理解的发展，更新了 GoU 对的结构特征。
