Park Moon Hyang, Jeon Seok Hoon, Kim Nam Hoon, Kang Moon Ja
Department of Pathology, Hanyang University, College of Medicine, Seoul, Korea.
Pathol Res Pract. 2002;198(6):435-9. doi: 10.1078/0344-0338-00278.
The laminated inclusions in the rough endoplasmic reticulum (RER) are peculiar structures seen only in some cases of chondrocytes of pseudoachondroplasia. These ultrastructurally unique organelles have not yet been reported in inflammatory malignant fibrous histiocytoma (MFH). We describe an omental mass showing unique laminated inclusions in the RER in a young man with intra-abdominal inflammatory MFH. The most striking ultrastructural feature was a dilated RER containing a fine granular substance and a more electron-dense material exhibiting an onion skin-like lamellated or maze-like pattern, mimicking that of so-called laminated inclusions. These lamellated inclusions occupied most of the cytoplasm of the tumor cells. We speculate that the ultrastructural finding of the laminated RER inclusion is not specific for cartilage cells, but may represent abnormal accumulation of some kind of glycoprotein material or matrix protein. This granular material may undergo organization to form a peculiar laminated structure, probably due to a metabolic or fixation process. Further study is needed to elucidate the nature of this material.
粗面内质网（RER）中的层状包涵体是仅在假性软骨发育不全的某些软骨细胞病例中可见的特殊结构。这些超微结构独特的细胞器在炎症性恶性纤维组织细胞瘤（MFH）中尚未见报道。我们描述了一名患有腹腔内炎症性MFH的年轻男性，其网膜肿块的RER中显示出独特的层状包涵体。最显著的超微结构特征是扩张的RER，其中含有细颗粒物质和电子密度更高的物质，呈现出洋葱皮样层状或迷宫样图案，类似于所谓的层状包涵体。这些层状包涵体占据了肿瘤细胞的大部分细胞质。我们推测，RER层状包涵体的超微结构发现并非软骨细胞所特有，可能代表某种糖蛋白物质或基质蛋白的异常积聚。这种颗粒物质可能经过组织形成特殊的层状结构，可能是由于代谢或固定过程所致。需要进一步研究以阐明这种物质的性质。
