早产儿出院时的周期性呼吸与血氧饱和度

Periodic breathing and oxygen saturation in preterm infants at discharge.

作者信息

Razi Nosrat M, DeLauter Michelle, Pandit Paresh B

机构信息

Division of Neonatology, Department of Pediatrics, The Children's Regional Hospital at Cooper Hospital and University Medical Center, Camden, NJ 08103, USA.

出版信息

J Perinatol. 2002 Sep;22(6):442-4. doi: 10.1038/sj.jp.7210762.

DOI:10.1038/sj.jp.7210762

PMID:12168119

Abstract

OBJECTIVE

Periodic breathing (PB) is a common respiratory pattern in preterm infants. Our aim was to determine the influence of PB on the pattern of oxygenation in preterm infants with significant PB at discharge from hospital.

STUDY DESIGN

Overnight 12-hour recordings of arterial O(2) saturation (SpO(2)), impedance breathing movement, nasal thermistor signals for airflow, and heart rate were performed in all preterm infants < or = 34 weeks' gestational age at birth, prior to hospital discharge. Infants had recovered from their neonatal complications and were not receiving methylxanthines or supplemental oxygen. Data from 28 infants who had significant PB (> or = 5% of quiet time artifact free) were further analyzed. Gestational age at birth was (median, range) 32 (27-34) weeks, and gestational age at recording was 35 (33-37) weeks.

RESULTS

The baseline SpO(2) was 98% (92-100%). During PB, all infants had episodes when SpO(2) fell > or = 5%, and all except one had episodes when SpO(2) was < 90%. Sixty episodes of prolonged desaturation (SpO(2) < or = 80% for >/ or = 4 seconds) were recorded in 10 infants: 31 occurred during PB, 16 during hypopnea, 10 during apnea, and 3 occurred in the absence of these breathing patterns. During PB, nine infants (32%) had 1 to 13 episodes of prolonged desaturation, lasting 9 (4-76) seconds.

CONCLUSION

We conclude that PB is a common cause of prolonged desaturation in preterm infants at discharge.

摘要

目的

周期性呼吸（PB）是早产儿常见的呼吸模式。我们的目的是确定PB对出院时存在明显PB的早产儿氧合模式的影响。

研究设计

对所有出生时胎龄小于或等于34周的早产儿在出院前进行为期12小时的夜间动脉血氧饱和度（SpO₂）、阻抗呼吸运动、鼻热敏电阻气流信号和心率记录。婴儿已从新生儿并发症中恢复，且未接受甲基黄嘌呤或补充氧气治疗。对28例存在明显PB（>或=安静时间无伪差的5%）的婴儿的数据进行进一步分析。出生时胎龄（中位数，范围）为32（27 - 34）周，记录时胎龄为35（33 - 37）周。

结果

基线SpO₂为98%（92 - 100%）。在PB期间，所有婴儿均有SpO₂下降>或=5%的情况，除1例婴儿外，所有婴儿均有SpO₂<90%的情况。10例婴儿记录到60次长时间低氧饱和度发作（SpO₂<或=80%持续>/或=4秒）：31次发生在PB期间，16次发生在呼吸浅慢时，10次发生在呼吸暂停时，3次发生在无这些呼吸模式时。在PB期间，9例婴儿（32%）有1至13次长时间低氧饱和度发作，持续9（4 - 76）秒。