Saletti A, Stick S, Doherty D, Simmer K
Department of Neonatal Paediatrics, King Edward Memorial/Princess Margaret Hospitals, Subiaco, WA 6008, Australia.
J Paediatr Child Health. 2004 Sep-Oct;40(9-10):519-23. doi: 10.1111/j.1440-1754.2004.00455.x.
To review our management of infants discharged home receiving supplemental oxygen. Stable preterm infants receive low flow O(2) by nasal cannulae aiming for SaO(2) of > or = 95%. Oxygen-dependent infants must pass an air test (ability to maintain SaO(2) > 80% during 4 h disconnection from oxygen) before discharge home with supplemental oxygen. A sleep study is performed before nocturnal O(2) is ceased.
Infants less than 33 weeks gestational age (GA) who were admitted January 1999-June 2001 and discharged home with supplemental oxygen were identified through the databases and medical records of the King Edward Memorial/Princess Margaret Hospitals. The data collected were compared with an audit performed a decade earlier.
Ninety-three infants were discharged home with supplemental oxygen between 1999 and 2001 (10% neonatal intensive care unit admissions less than 33 weeks GA; median GA 26 weeks (interquartile range 25-28). All infants had an air test before discharge: 63% failed the first air test and 30% at least two air tests. The median delay between the first air test and discharge was 2 weeks. The median postmenstrual age at discharge was 40 weeks gestation (interquartile range 38-41). Ninety infants had a sleep study before nocturnal oxygen was ceased and nine failed the first sleep study. Hospital readmission rate was 60%. More preterm infants (less than 33 weeks) were discharged with supplemental oxygen in 1999-2001 (10%, n = 96 in 1999-2001) than in 1987-1992 (2.5%, n = 53) and this was associated with an earlier discharge (40 vs 44 weeks postmenstrual age), lower oxygen requirements at discharge (60 vs 125 mL/min), earlier discontinuation of daytime and nocturnal oxygen (1 vs 4 months postmenstrual age and 2.5 vs 6 months postmenstrual age) and no increase in readmission rate (64% vs 60%). The incidence of bronchopulmonary dysplasia for these infants has remained stable at 20%.
Our home oxygen programme, based on an air test predischarge and a sleep study prediscontinuation of nocturnal oxygen, facilitates early discharge home. Our data suggest that over the last decade, bronchopulmonary dysplasia is associated with less impairment in lung function. Further evidence from randomized clinical trials is required to determine optimal target range for oxygen saturation in preterm infants.
回顾我们对出院时仍需补充氧气的婴儿的管理情况。稳定的早产儿通过鼻导管接受低流量氧气,目标是使血氧饱和度(SaO₂)≥95%。依赖氧气的婴儿在出院回家并携带补充氧气之前,必须通过空气测试(在与氧气断开连接4小时期间能够维持SaO₂>80%)。在夜间停止吸氧之前要进行睡眠研究。
通过爱德华国王纪念医院/玛格丽特公主医院的数据库和病历,确定1999年1月至2001年6月入院且出院时携带补充氧气的孕周小于33周(GA)的婴儿。将收集的数据与十年前进行的一次审计结果进行比较。
1999年至2001年期间,有93名婴儿出院时携带补充氧气(占孕周小于33周的新生儿重症监护病房入院人数的10%;GA中位数为26周(四分位间距为25 - 28周))。所有婴儿在出院前都进行了空气测试:63%的婴儿首次空气测试未通过,30%的婴儿至少两次空气测试未通过。首次空气测试与出院之间的中位延迟时间为2周。出院时的月经后年龄中位数为40周妊娠(四分位间距为38 - 41周)。90名婴儿在夜间停止吸氧之前进行了睡眠研究,9名婴儿首次睡眠研究未通过。医院再入院率为60%。1999 - 2001年期间出院时携带补充氧气的孕周小于33周的早产儿(10%,1999 - 2001年n = 96)比1987 - 1992年(2.5%,n = 53)更多,这与更早出院(月经后年龄40周对44周)、出院时更低的氧气需求量(60对125 mL/分钟)、更早停止白天和夜间吸氧(月经后年龄1个月对4个月以及2.5个月对6个月)以及再入院率没有增加(64%对60%)相关。这些婴儿的支气管肺发育不良发生率一直稳定在20%。
我们基于出院前空气测试和夜间停止吸氧前睡眠研究的家庭氧疗方案,有助于婴儿早日出院回家。我们的数据表明,在过去十年中,支气管肺发育不良与肺功能损害较轻相关。需要随机临床试验的进一步证据来确定早产儿氧饱和度的最佳目标范围。