顶头孢霉生产头孢菌素C的菌株改良研究。
Strain improvement studies for cephalosporin C production by Cephalosporium acremonium.
作者信息
Ellaiah P, Adinarayana K, Chand G Murali, Subramanyam G S V, Srinivasulu B
机构信息
Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India.
出版信息
Pharmazie. 2002 Jul;57(7):489-90.
PMID:12168534
Abstract
Treatment of spore suspension of Cephalosporium acremonium ATCC 48272 with UV rays and N-methyl-N-nitro-N-nitrosoguanidine (NTG) induced mutants capable of producing higher yields of cephalosporin C. Antibiotic yield was improved from 630 micrograms/ml to 1995 micrograms/ml of the broth resulting in a high yielding mutant.
摘要
用紫外线和N-甲基-N-硝基-N-亚硝基胍（NTG）处理顶头孢霉ATCC 48272的孢子悬浮液，诱导出了能够产生更高产量头孢菌素C的突变体。抗生素产量从每毫升肉汤630微克提高到了1995微克，从而得到了一个高产突变体。
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