Membrane association and kinase-like motifs of the RamC protein of Streptomyces coelicolor.
作者信息
Hudson Michael E, Zhang Dachuan, Nodwell Justin R
机构信息
Department of Biochemistry and Antimicrobial Research Centre, McMaster University, 200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.
出版信息
J Bacteriol. 2002 Sep;184(17):4920-4. doi: 10.1128/JB.184.17.4920-4924.2002.
Abstract
The protein RamC is required for the production of the spore-forming cells called aerial hyphae by the filamentous bacterium Streptomyces coelicolor. We showed that RamC, which contains several weakly predicted membrane-spanning sequences, is located exclusively in the S. coelicolor membrane. By constructing site-directed mutants in the cloned ramC gene and complementing a ramC null mutant, we showed that protein kinase-like sequence motifs in the amino-terminal half of the protein are required for function in vivo. These data suggest that RamC is a membrane-associated receptor kinase.
摘要
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