Huth F, Herbertz G, Dörfel T, Soren A
Z Orthop Ihre Grenzgeb. 1975 Dec;113(6):1005-10.
Sixty knee joints of 49 autopsies and 10 amputated legs were examined histologically by specimens removed from eight locations. The criteria considered were: configuration of the surface, number of rows of synovial cells, sizes of bodies and nuclei of the synovial cells, position of the blood vessels to the synovial surface, degree of sclerosis both of the subsynovial connective tissue and blood vessels, and infiltrates of inflammatory cells. These parameters were recorded in tables, and 3,600 individual data were statistically evaluated by the aid of a PDP-12-computer. Survey of all findings shows that the age changes of the synovial membrane are relatively slight. With increasing body weight sclerosis of the synovial blood vessels progresses, but these vessels are sometimes spared in generalized arteriosclerosis. The greatest number of individual tissue changes is noted in the fat pad, medial and lateral capsular parts. Thus the synovial membrane of these parts may be regarded prominently reactive and of special value for the diagnosis of synovial changes. Since these parts are easily accessible at routine arthrotomies, they are recommended as the sites for diagnostic biopsies.
对49例尸体解剖和10条截肢腿的60个膝关节进行了组织学检查，从八个部位取出标本。考虑的标准有：表面形态、滑膜细胞层数、滑膜细胞体和细胞核大小、血管与滑膜表面的位置关系、滑膜下结缔组织和血管的硬化程度以及炎性细胞浸润情况。这些参数记录在表格中，并借助PDP - 12计算机对3600个个体数据进行了统计学评估。对所有检查结果的调查表明，滑膜的年龄变化相对较小。随着体重增加，滑膜血管硬化进展，但在全身性动脉硬化时，这些血管有时可幸免。在脂肪垫、内侧和外侧关节囊部位观察到的个体组织变化最多。因此，这些部位的滑膜可被视为反应明显且对滑膜变化诊断具有特殊价值。由于这些部位在常规关节切开术中易于触及，建议将其作为诊断性活检的部位。
