Pabst Reinhard, Tschernig Thomas
Department of Functional and Applied Anatomy, Medical School of Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
J Allergy Clin Immunol. 2002 Aug;110(2):209-14. doi: 10.1067/mai.2002.126836.
In allergic and inflammatory immune reactions of the respiratory tract, leukocytes migrate into the different compartments of the lung. The air space can easily be sampled by means of bronchoalveolar lavage. However, the subset composition in the bronchial wall or the lung interstitium often differs considerably from that of the bronchoalveolar lavage fluid. A further compartment involved in very heterogeneous immune reactions in the lung has thus far not been mentioned: the periarterial space. In numerous experiments in different species with virus, bacteria, fungi, or allergens, there was not only a leukocyte infiltration of the bronchial lamina propria but also infiltration around branches of the pulmonary artery. This thus far neglected compartment consists of a different type of capillary. Thus it is important not to overlook this area in studies on allergic or inflammatory immune reactions of the lung.
在呼吸道的过敏性和炎症性免疫反应中，白细胞迁移至肺的不同区域。通过支气管肺泡灌洗可轻松采集肺泡腔样本。然而，支气管壁或肺间质中的亚群组成往往与支气管肺泡灌洗液有很大差异。迄今为止尚未提及的肺中参与非常异质性免疫反应的另一个区域是动脉周围间隙。在针对不同物种进行的众多涉及病毒、细菌、真菌或过敏原的实验中，不仅支气管固有层有白细胞浸润，肺动脉分支周围也有浸润。这个迄今为止被忽视的区域由一种不同类型的毛细血管组成。因此，在关于肺的过敏性或炎症性免疫反应的研究中，重要的是不要忽略这个区域。
