一氧化氮合酶抑制剂L-NAME对新生白化大鼠心肌在出生后早期个体发育过程中DNA合成的影响。
Effect of NO synthase inhibitor L-NAME on DNA synthesis in the myocardium of albino rats during early postnatal ontogeny.
作者信息
Sazonova E N, Pikalova V M, Timoshin S S
机构信息
Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk.
出版信息
Bull Exp Biol Med. 2002 Jan;133(1):20-2. doi: 10.1023/a:1015183822743.
Effects of repeated treatment (5 times) with L-NAME, a NO synthase (eNOS) inhibitor on DNA synthesis in various zones of the heart in newborn albino rats was studied using 3H-thymidine autoradiography. This compound decreased (by 1.22-1.59 times) the count of labeled cardiomyocyte nuclei in various myocardial zones, particularly, in the myocardium of the left atrium, left ventricle, and interventricular septum. Changes in tissue proliferative activity were accompanied by activation of lipid peroxidation and inhibition of the antioxidant system in the myocardium.
使用3H-胸腺嘧啶核苷放射自显影术研究了一氧化氮合酶（eNOS）抑制剂L-NAME对新生白化大鼠心脏不同区域DNA合成的重复治疗（5次）效果。该化合物使不同心肌区域，特别是左心房、左心室和室间隔心肌中标记的心肌细胞核计数减少（减少1.22 - 1.59倍）。组织增殖活性的变化伴随着心肌中脂质过氧化的激活和抗氧化系统的抑制。
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