Prieto Victor G, Clark Sandra H
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, USA.
Ann Diagn Pathol. 2002 Aug;6(4):257-64. doi: 10.1053/adpa.2002.35400.
Within the last years, evaluation of sentinel lymph nodes (SLN) has become the most popular method of early staging of several malignancies, including breast carcinoma and melanoma. Because SLN are reportedly the lymph nodes most likely to contain metastatic deposits, identification of such nodes allows pathologists to examine the tissue in a much more intense manner than with the usual lymphadenectomy specimens containing multiple lymph nodes. However, there is not a universally accepted standard protocol for pathologic processing of the SLN. Initially, the most popular protocols called for bisection of the SLN and examination of serial sections, with or without routinely performed immunohistochemistry. Lately, other protocols have been proposed to try to simplify the histologic analysis while providing at least equivalent results. Here we review the different protocols used for the evaluation of SLN and describe the protocol currently in use at M. D. Anderson Cancer Center (Houston, TX).
在过去几年中，前哨淋巴结（SLN）评估已成为包括乳腺癌和黑色素瘤在内的几种恶性肿瘤早期分期最常用的方法。据报道，由于前哨淋巴结是最有可能含有转移灶的淋巴结，识别这些淋巴结可使病理学家比检查含有多个淋巴结的常规淋巴结切除标本更深入地检查组织。然而，对于前哨淋巴结的病理处理，目前尚无普遍接受的标准方案。最初，最常用的方案要求将前哨淋巴结对半切开并检查连续切片，同时或不进行常规免疫组织化学检查。最近，有人提出了其他方案，试图简化组织学分析，同时提供至少相当的结果。在此，我们回顾用于评估前哨淋巴结的不同方案，并描述目前德克萨斯大学MD安德森癌症中心（休斯顿，德克萨斯州）正在使用的方案。
