Prieto Victor G
Department of Pathology, University of Texas-MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 85, Houston, TX 77030, USA; Department of Dermatology, University of Texas-MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 85, Houston, TX 77030, USA.
Clin Lab Med. 2017 Sep;37(3):417-430. doi: 10.1016/j.cll.2017.05.002. Epub 2017 Jun 29.
Examination of sentinel lymph nodes (SLNs) has probably become the most popular method of early staging of patients with cutaneous melanoma. SLNs are considered to be the most likely ones to contain metastatic deposits; thus, they can be examined in a more intense manner than in standard lymphadenectomy. Most processing protocols use formalin-fixed, paraffin-embedded sections stained with hematoxylin-eosin with the addition of immunohistochemistry. Approximately 20% of patients with cutaneous melanoma show melanoma cells in the SLNs. Different methods of quantification of tumor burden in SLNs provide clinically important prognostic information.
前哨淋巴结（SLN）检查可能已成为皮肤黑色素瘤患者早期分期最常用的方法。前哨淋巴结被认为是最有可能含有转移灶的淋巴结；因此，与标准淋巴结清扫术相比，可以更深入地对其进行检查。大多数处理方案采用苏木精-伊红染色并添加免疫组织化学的福尔马林固定、石蜡包埋切片。约20%的皮肤黑色素瘤患者的前哨淋巴结中可发现黑色素瘤细胞。前哨淋巴结中肿瘤负荷的不同量化方法可提供重要的临床预后信息。
