锂对脑突触体摄取多巴胺的影响。

Effect of lithium on dopamine uptake by brain synaptosomes.

作者信息

Stefanini E, Argiolas A, Gessa G L, Fadda F

机构信息

Institute of Pharmacology, University of Cagliari, Italy.

出版信息

J Neurochem. 1976 Nov;27(5):1237-9. doi: 10.1111/j.1471-4159.1976.tb00333.x.

DOI:10.1111/j.1471-4159.1976.tb00333.x

PMID:12170613

Abstract

Lithium chloride exerts two opposite effects on dopamine uptake by synaptosomes isolated from rat caudate nucleus. Added in vitro, it inhibits dopamine uptake; whereas administered chronically in vivo, it enhances dopamine uptake in vitro. Thus, in vitro, 1, 2.5, 5 and 10 meqiv.l-1 of lithium chloride decrease [3H]dopamine uptake by 13, 17, 25 and 31%, respectively. Synaptosomes isolated from rats treated with lithium chloride for 20 days, show a 23% increase in [3H]dopamine uptake with respect to synaptosomes isolated from control rats. It is suggested that chronic lithium treatment stimulates a compensatory mechanism which overcomes its direct inhibitory effect on [3H]dopamine uptake.

摘要

氯化锂对从大鼠尾状核分离出的突触体摄取多巴胺有两种相反的作用。在体外添加时，它会抑制多巴胺摄取；而在体内长期给药时，它会增强体外多巴胺摄取。因此，在体外，1、2.5、5和10毫当量/升的氯化锂分别使[3H]多巴胺摄取减少13%、17%、25%和31%。用氯化锂处理20天的大鼠分离出的突触体，与从对照大鼠分离出的突触体相比，[3H]多巴胺摄取增加了23%。有人提出，长期锂治疗会刺激一种补偿机制，该机制克服了其对[3H]多巴胺摄取的直接抑制作用。