Plenge P
Psychopharmacology (Berl). 1982;77(4):348-55. doi: 10.1007/BF00432769.
The effects of lithium on several brain energy metabolites were investigated in rats. Lithium was administered by three alternative routes: 1) in food, 2) via IP injection, or 3) intracisternally via the suboccipital route. Lithium given in food induced permanent changes, mainly in glycolytic processes and in glycogen content. Lithium injected IP induced, in addition, several changes which depended on the increase in brain lithium concentration following injection of lithium. These changes in brain metabolites disappeared as brain lithium concentration stabilized. Intracisternal injection of lithium produced brain lithium concentrations between 1 and 2 mmoles/kg wet wt., with a mean of about 1.6 mmoles/kg wet wt. Lithium concentrations below about 1.6 mmoles/kg wet wt. induced changes in brain metabolites which were similar to the changes seen after IP injection of lithium. Lithium concentrations above about 1.6 mmoles/kg wet wt. induced changes in several brain metabolites which were at variance with the changes induced by lower lithium concentrations. These changes were in many respects similar to changes in brain metabolites seen in rats exposed to convulsive treatment. It is hypothesized that such metabolic changes during lithium treatment, in discrete areas of the brain with higher concentration of lithium, e.g., hypothalamus, might be related to the prophylactic effect of lithium treatment in man.
在大鼠中研究了锂对几种脑能量代谢物的影响。锂通过三种不同途径给药：1）加入食物中，2）腹腔注射，或3）经枕下途径脑池内注射。加入食物中的锂会引起永久性变化，主要是在糖酵解过程和糖原含量方面。腹腔注射锂还会引起一些变化，这些变化取决于注射锂后脑内锂浓度的升高。随着脑内锂浓度稳定，脑代谢物的这些变化消失。脑池内注射锂产生的脑锂浓度在1至2毫摩尔/千克湿重之间，平均约为1.6毫摩尔/千克湿重。低于约1.6毫摩尔/千克湿重的锂浓度引起的脑代谢物变化与腹腔注射锂后观察到的变化相似。高于约1.6毫摩尔/千克湿重的锂浓度引起几种脑代谢物的变化，这些变化与较低锂浓度引起的变化不同。这些变化在许多方面与接受惊厥治疗的大鼠脑代谢物的变化相似。据推测，锂治疗期间在脑内锂浓度较高的离散区域（如下丘脑）发生的这种代谢变化可能与人中锂治疗的预防作用有关。
