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长期锂治疗大鼠体内锂对大鼠脑葡萄糖代谢的影响。

Lithium effects on rat brain glucose metabolism in long-term lithium-treated rats studied in vivo.

作者信息

Plenge P

出版信息

Psychopharmacology (Berl). 1978 Jul 19;58(3):317-22. doi: 10.1007/BF00427398.

DOI:10.1007/BF00427398
PMID:98804
Abstract

The time course of lithium effects on several brain energy metabolites has been investigated in rats. The rats were injected once daily with lithium chloride and killed by freezing in liquid nitrogen 1--8 h after the last injection. The effect of lithium was most marked in the period in which the brain lithium concentration was increasing, whereas the effect was wearing off when the brain lithium concentration had stabilized, even though the lithium concentration was higher. These results led to the hypothesis that the effect of lithium on several parameters depends on the increase in lithium concentration following the administration of lithium, rather than on the absolute concentration of lithium.

摘要

已经在大鼠中研究了锂对几种脑能量代谢物影响的时间进程。大鼠每天注射一次氯化锂，并在最后一次注射后1至8小时通过在液氮中冷冻处死。锂的作用在脑锂浓度增加的时期最为明显，而当脑锂浓度稳定时，这种作用逐渐消失，尽管锂浓度更高。这些结果导致了这样一种假设，即锂对几个参数的影响取决于锂给药后锂浓度的增加，而不是锂的绝对浓度。

相似文献

1
Lithium effects on rat brain glucose metabolism in long-term lithium-treated rats studied in vivo.长期锂治疗大鼠体内锂对大鼠脑葡萄糖代谢的影响。
Psychopharmacology (Berl). 1978 Jul 19;58(3):317-22. doi: 10.1007/BF00427398.
2
Lithium effects on rat brain glucose metabolism in vivo. Effects after administration of lithium by various routes.锂对大鼠脑内葡萄糖代谢的体内效应。通过不同途径给予锂后的效应。
Psychopharmacology (Berl). 1982;77(4):348-55. doi: 10.1007/BF00432769.
3
Correlation of lithium effect on electroshock-induced seizure in rats with its concentration in brain and plasma.锂对大鼠电休克诱发惊厥的作用与其在脑和血浆中浓度的相关性。
Arch Int Pharmacodyn Ther. 1982 Jan;255(1):81-8.
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Acute lithium effects on rat brain glucose metabolism - in vivo.急性锂对大鼠脑葡萄糖代谢的体内效应
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Plasma and brain lithium levels after lithium carbonate and lithium chloride administration by different routes in rats.大鼠经不同途径给予碳酸锂和氯化锂后血浆及脑内锂水平
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The effect of the combination of lithium and haloperidol on brain intermediary metabolism in vivo.锂盐与氟哌啶醇联合应用对体内脑中间代谢的影响。
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Effects of lithium on brain energy reserves and cations in vivo.锂对体内脑能量储备和阳离子的影响。
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Changes in rat brain monoamine metabolism following the acute administration of lithium chloride in combination with antidepressant drugs.氯化锂与抗抑郁药物联合急性给药后大鼠脑单胺代谢的变化。
Arch Int Pharmacodyn Ther. 1975 Jun;215(2):202-7.
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In vitro and in vivo inhibition by lithium of enkephalin binding to opiate receptors in rat brain.锂在体外和体内对脑啡肽与大鼠脑内阿片受体结合的抑制作用。
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引用本文的文献

1
Lithium effects on rat brain glucose metabolism in vivo. Effects after administration of lithium by various routes.锂对大鼠脑内葡萄糖代谢的体内效应。通过不同途径给予锂后的效应。
Psychopharmacology (Berl). 1982;77(4):348-55. doi: 10.1007/BF00432769.
2
Lithium effects on citrate metabolism in humans and rats.锂对人类和大鼠柠檬酸盐代谢的影响。
Psychopharmacology (Berl). 1981;73(1):75-6. doi: 10.1007/BF00431105.
3
Lithium treatment regimens induce different changes in [3H]paroxetine binding protein and other rat brain proteins.锂治疗方案会引起[3H]帕罗西汀结合蛋白及其他大鼠脑蛋白的不同变化。

本文引用的文献

1
Prophylactic electroshock a five year study.预防性电击：一项为期五年的研究。
Am J Psychiatry. 1951 Apr;107(10):743-8. doi: 10.1176/ajp.107.10.743.
2
INFLUENCE OF LI+ ON GLUCOSE METABOLISM IN RATS AND RABBITS.锂对大鼠和家兔葡萄糖代谢的影响。
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Influence of ions on the uptake of glucose and on the effect of insulin on it by rat diaphragm.离子对大鼠膈肌摄取葡萄糖的影响以及对胰岛素作用于葡萄糖摄取的影响。
Psychopharmacology (Berl). 1992;106(1):131-5. doi: 10.1007/BF02253600.
Nature. 1959 Jan 31;183(4657):324-5. doi: 10.1038/183324a0.
4
Effect of lithium on dopamine uptake by brain synaptosomes.锂对脑突触体摄取多巴胺的影响。
J Neurochem. 1976 Nov;27(5):1237-9. doi: 10.1111/j.1471-4159.1976.tb00333.x.
5
The relationship between the transport of glucose and cations across cell membranes in isolated tissues.分离组织中葡萄糖和阳离子跨细胞膜转运之间的关系。
Biochim Biophys Acta. 1968 Jan 3;150(1):66-72. doi: 10.1016/0005-2736(68)90009-6.
6
Lithium action on glycogen synthesis in rat brain, liver, and diaphragm.锂对大鼠脑、肝及膈肌糖原合成的作用。
J Psychiatr Res. 1970 Oct;8(1):29-36. doi: 10.1016/0022-3956(70)90013-0.
7
Effects of lithium on amino-acids in mouse brain in vivo.锂对小鼠脑内氨基酸的体内效应。
Nature. 1970 Feb 21;225(5234):749-50. doi: 10.1038/225749a0.
8
Effect of lithium on concentrations of glutamate and GABA levels in amygdala and hypothalamus of rat.锂对大鼠杏仁核和下丘脑谷氨酸浓度及γ-氨基丁酸水平的影响。
Nat New Biol. 1971 Nov 24;234(47):124-5. doi: 10.1038/newbio234124a0.
9
The relationship between the transport of glucose and cations across cell membranes in isolated tissues. VII. The effects of extracellular Na + and K + on the transport of 3-O-methylglucose and glucose in rat soleus muscle.离体组织中葡萄糖与阳离子跨细胞膜转运的关系。VII. 细胞外Na⁺和K⁺对大鼠比目鱼肌中3 - O - 甲基葡萄糖和葡萄糖转运的影响。
Biochim Biophys Acta. 1972 Mar 17;255(3):798-814. doi: 10.1016/0005-2736(72)90392-6.
10
Effects of LI + on the metabolism in brain of glutamate, glutamine, aspartate and GABA from (1- 14 C)acetate in vitro.锂离子对体外培养的（1-¹⁴C）乙酸盐中谷氨酸、谷氨酰胺、天冬氨酸和γ-氨基丁酸在脑内代谢的影响。
Brain Res. 1972 Jan 14;36(1):203-13. doi: 10.1016/0006-8993(72)90776-7.