Goossens Valère J, Schreij Gerrit, van der Geest Siebe, Van Leeuwen Danitsja M, Baas Dominique C, Bruggeman Cathrien A, van der Ven André J
Department of Medical Microbiology, University Hospital Maastricht, Maastricht, the Netherlands.
AIDS. 2002 Aug 16;16(12):1682-4. doi: 10.1097/00002030-200208160-00015.
After the successful initiation of highly active antiretroviral therapy (HAART) in HIV-1-infected patients, the mean CD4 cell response was lower in cytomegalovirus (CMV)-seropositive patients than in CMV-seronegative patients (P < 0.05). The difference between the mean CD4 cell counts of CMV-seronegative and CMV-seropositive patients was maximal (163 x 10(6)/l) at 76 weeks after the start of HAART, and decreased gradually thereafter. No association was found between herpes simplex virus types 1 and 2 serostatus and CD4 cell response.
在HIV-1感染患者成功启动高效抗逆转录病毒疗法（HAART）后，巨细胞病毒（CMV）血清反应阳性患者的平均CD4细胞反应低于CMV血清反应阴性患者（P<0.05）。HAART开始后76周时，CMV血清反应阴性和血清反应阳性患者的平均CD4细胞计数差异最大（163×10⁶/l），此后逐渐减小。未发现1型和2型单纯疱疹病毒血清状态与CD4细胞反应之间存在关联。
