Cherepova N, Mihailova L, Gulubov S
Zentralbl Bakteriol Orig A. 1975 Oct;233(2):245-52.
Altered and L-forms of Erysipelothrix rhusiopathiae were obtained through in vitro and in vivo treatments with novobiocin. Electron microscopic studies were carried out on the changes taking place in the morphology and ultrastructure of strains showing a varying degree of resistance. When lower concentrations of the antibiotic were employed (15, 25, 200, 400 mcg) strongly elongated and threadlike forms were established manifesting characteristic changes in the cell wall and the inner structure. The use of high concentrations of novobiocin (1000 and 2000 mcg) incited the production of L-forms the morphology and ultrastructure of which are dealt with in detail.
通过用新生霉素进行体外和体内处理，获得了猪丹毒杆菌的变异型和L型。对表现出不同程度抗性的菌株的形态和超微结构变化进行了电子显微镜研究。当使用较低浓度的抗生素（15、25、200、400微克）时，会形成强烈伸长的丝状形态，细胞壁和内部结构出现特征性变化。使用高浓度的新生霉素（1000和2000微克）会促使L型的产生，其形态和超微结构将被详细阐述。
