Iwado Yasuyoshi, Yoshinaga Keiichiro, Furuyama Hideto, Ito Yoshinori, Noriyasu Kazuyuki, Katoh Chietsugu, Kuge Yuji, Tsukamoto Eriko, Tamaki Nagara
Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Kita-Ku, Kita 15 Nishi 7, Sapporo, 060-8638, Japan.
Eur J Nucl Med Mol Imaging. 2002 Aug;29(8):984-90. doi: 10.1007/s00259-002-0818-1. Epub 2002 Apr 30.
Chronic cigarette smoking alters coronary vascular endothelial response. To determine whether altered response also occurs in young individuals without manifest coronary disease we quantified coronary blood flow at rest, following adenosine vasodilator stress and during the cold pressor test in healthy young smokers. Myocardial blood flow (MBF) was quantified by oxygen-15 labelled water positron emission tomography in 30 healthy men aged from 20 to 35 years (18 smokers and 12 non-smokers, aged 27.4 +/- 4.4 vs 26.3 +/- 3.3). The smokers had been smoking cigarettes for 9.4 +/- 4.9 pack-years. MBF was measured at rest, during intravenous adenosine triphosphate (ATP: 0.16 mg kg(-1) min(-1)) infusion (hyperaemic response), and during cold pressor test (CPT) (endothelial vasodilator response). Rest MBF and hyperaemic MBF did not differ significantly between the smokers and the non-smokers (rest: 0.86 +/- 0.11 vs 0.92 +/- 0.14 and ATP: 3.20 +/- 1.12 vs 3.69 +/- 0.76 ml g(-1) min(-1); P = NS). Coronary flow reserve was similar between the two groups (smokers: 3.78 +/- 1.83; non-smokers: 4.03 +/- 0.68; P = NS). Although CPT induced a similar increase in rate-pressure product (RPP) in the smokers and the non-smokers (10,430 +/- 1,820 vs 9,236 +/- 1,356 beats min(-1) mmHg(-1)), CPT MBF corrected by RPP was significantly decreased in the smokers (0.65 +/- 0.12 ml g(-1) min(-1)) compared with the non-smokers (0.87 +/- 0.12 ml g(-1) min(-1)) ( P < 0.05). In addition, the ratio of CPT MBF to resting MBF was inversely correlated with pack-years ( r = -0.57, P = 0.014). Endothelium-dependent coronary artery vasodilator function is impaired in apparently healthy young smokers.
长期吸烟会改变冠状动脉血管内皮反应。为了确定这种改变的反应是否也发生在没有明显冠心病的年轻人中，我们对健康年轻吸烟者在静息状态、腺苷血管扩张应激后以及冷加压试验期间的冠状动脉血流进行了量化。通过氧-15标记水正电子发射断层扫描对30名年龄在20至35岁之间的健康男性（18名吸烟者和12名不吸烟者，年龄分别为27.4±4.4岁和26.3±3.3岁）的心肌血流（MBF）进行了量化。吸烟者的吸烟量为9.4±4.9包年。在静息状态、静脉输注三磷酸腺苷（ATP：0.16 mg kg⁻¹ min⁻¹）期间（充血反应）以及冷加压试验（CPT）期间（内皮血管扩张反应）测量MBF。吸烟者和不吸烟者的静息MBF和充血MBF无显著差异（静息：0.86±0.11 vs 0.92±0.14，ATP：3.20±1.12 vs 3.69±0.76 ml g⁻¹ min⁻¹；P =无显著性差异）。两组之间的冠状动脉血流储备相似（吸烟者：3.78±1.83；不吸烟者：4.03±0.68；P =无显著性差异）。尽管CPT在吸烟者和不吸烟者中引起的心率-血压乘积（RPP）升高相似（10430±1820 vs 9236±1356次/分钟·毫米汞柱⁻¹），但与不吸烟者（0.87±0.12 ml g⁻¹ min⁻¹）相比，吸烟者经RPP校正的CPT MBF显著降低（0.65±0.12 ml g⁻¹ min⁻¹）（P < 0.05）。此外，CPT MBF与静息MBF的比值与吸烟包年数呈负相关（r = -0.57，P = 0.014）。在看似健康的年轻吸烟者中，内皮依赖性冠状动脉血管扩张功能受损。
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