Kucheriavenko V S, Sokhin A A, Logvinova V M, Barilo V N, Moshiashvili I Ia
Zh Mikrobiol Epidemiol Immunobiol. 1975 Dec(12):100-4.
An extended controlled epidemiological trial was carried out for the purpose of studying the reactogenic properties, immunological and epidemiological efficacy of immunization against whooping cough, diphtheria and tetanus according to a scheme suggested by the authors (AKdeltaC-AKdeltaC-KB) in comparison with the official scheme (AKdeltaC-AKdeltaC-AKdeltaC). There was revealed some increase in the frequency of general reactions in children vaccinated by the experimental scheme; however strong general reactions and local reactions of different intensity were encountered with equal frequency in both groups. Two months after the end of the vaccination significantly higher titres of pertussis agglutinins were revealed in children immunized by the AKdeltaC-AKdeltaC-KB scheme; no significant difference was found in the content of the protective titres of diphtheria and tetanus antitoxins. The duration of preservation of postvaccinal antibodies against all the AKdeltaC-vaccine components and increase in their amount after the first revaccination (in 1.5-2 years) was the same in both the groups of children. A greater epidemiological efficacy of pertussis antigen was revealed by prolonged observation in immunization by the AKdeltaC-AKdeltaC-KB sheme in comparison with immunization by the official scheme (pertussis incidence per 100 thousand children proved to be 12.7 and 71.2, respectively).
为了研究按照作者建议的方案（AKdeltaC - AKdeltaC - KB）接种百日咳、白喉和破伤风疫苗的反应原性、免疫和流行病学效果，并与官方方案（AKdeltaC - AKdeltaC - AKdeltaC）进行比较，开展了一项扩展的对照流行病学试验。结果显示，采用试验方案接种疫苗的儿童中，一般反应的频率有所增加；然而，两组中出现强烈一般反应和不同强度局部反应的频率相同。接种结束两个月后，采用AKdeltaC - AKdeltaC - KB方案免疫的儿童中，百日咳凝集素滴度显著更高；白喉和破伤风抗毒素的保护性滴度含量未发现显著差异。两组儿童中，针对所有AKdeltaC疫苗成分的疫苗后抗体保存时间以及首次复种（1.5 - 2年后）后抗体量的增加情况相同。与官方方案免疫相比，通过对采用AKdeltaC - AKdeltaC - KB方案免疫的儿童进行长期观察发现，百日咳抗原具有更高的流行病学效果（每十万名儿童中的百日咳发病率分别为12.7和71.2）。
