Stähr Peter, Voigtländer Thomas, Rupprecht Hans-Jürgen, Aschenbrücker Patrick, Mamtimin Hayraet, Brennecke Rüdiger, Otto Mike, Fitzgerald Peter J, Meyer Jürgen
Stanford University Medical School, CA 94305, USA.
J Am Soc Echocardiogr. 2002 Aug;15(8):823-30. doi: 10.1067/mje.2002.120700.
Three-dimensional intravascular ultrasound (IVUS) is used for volumetric assessment of arteriosclerotic plaque burden and restenotic tissue at follow-up after coronary interventions. However, the accuracy of these measurements, especially in tortuous vessels, is unclear.
A commercially available electrocardiogram (ECG)-gated 3-dimensional-IVUS system was tested in volume-validated straight and curved hydrocolloid phantoms and in volume-validated coronary specimens. Catheter withdrawal (30 MHz, 3.2F) was triggered using standardized ECG source with 0.2-mm step intervals per cardiac cycle simulation.
On the basis of automated phantom volume measurements, IVUS overestimated true phantom volume (relative error = [measured V - true V]/true V x 100) by a median of 0.9%, 0.25%, and 1.96% for straight, mildly curved, and severely curved segments, respectively. The true volume of the coronary specimens was overestimated by a median of 5.79%.
A median percentage deviation of 3-dimensional-IVUS-measured volumes from the true volumes of less than 10% in phantoms and coronary artery segments can be achieved.
三维血管内超声（IVUS）用于冠状动脉介入治疗后随访时对动脉粥样硬化斑块负荷和再狭窄组织进行容积评估。然而，这些测量的准确性，尤其是在血管迂曲的情况下，尚不清楚。
使用市售的心电图（ECG）门控三维IVUS系统，在经过容积验证的直形和弯曲水胶体模型以及经过容积验证的冠状动脉标本中进行测试。使用标准化的ECG源触发导管回撤（30MHz，3.2F），每个心动周期模拟的步长间隔为0.2mm。
基于自动模型容积测量，对于直形、轻度弯曲和重度弯曲节段，IVUS分别高估了模型的真实容积（相对误差=[测量容积-真实容积]/真实容积×100），中位数分别为0.9%、0.25%和1.96%。冠状动脉标本的真实容积被高估，中位数为5.79%。
在模型和冠状动脉节段中，三维IVUS测量的容积与真实容积的中位数百分比偏差可达到小于10%。
