Rupes Ivan
Department of Biology, Queen's University, Kingston, Ontario, Canada K7L 3N6.
Trends Genet. 2002 Sep;18(9):479-85. doi: 10.1016/s0168-9525(02)02745-2.
To remain viable, cells have to coordinate cell growth with cell division. In yeast, this occurs at two control points: the boundaries between G1 and S phases, also known as Start, and between G2 and M phases. Theoretically, coordination can be achieved by independent regulation of growth and division, or by participation of surveillance mechanisms in which cell size feeds back into cell-cycle control. This article discusses recent advances in the identification of sizing mechanisms in budding and in fission yeast, and how these mechanisms integrate with environmental stimuli. A comparison of the G1-S and G2-M size-control modules in the two species reveals a degree of conservation higher than previously thought. This reinforces the notion that internal sizing could be a conserved feature of cell-cycle control throughout eukaryotes.
为了保持活力，细胞必须协调细胞生长与细胞分裂。在酵母中，这发生在两个控制点：G1期和S期之间的边界，也称为起始点，以及G2期和M期之间的边界。理论上，协调可以通过独立调节生长和分裂来实现，或者通过监测机制来参与，在监测机制中细胞大小反馈到细胞周期控制中。本文讨论了在芽殖酵母和裂殖酵母中确定大小调节机制的最新进展，以及这些机制如何与环境刺激整合。对这两个物种中G1-S和G2-M大小控制模块的比较揭示了比以前认为的更高程度的保守性。这强化了内部大小调节可能是整个真核生物细胞周期控制的一个保守特征的观点。
