Renard D, Robert P, Lavenant L, Melcion D, Popineau Y, Guéguen J, Duclairoir C, Nakache E, Sanchez C, Schmitt C
INRA Centre de Recherches de Nantes, rue de la Geraudiere, BP 71627 44316 Cedex 3, Nantes, France.
Int J Pharm. 2002 Aug 21;242(1-2):163-6. doi: 10.1016/s0378-5173(02)00143-6.
Biopolymers represent an interesting alternative to synthetic polymers in order to be used as structured carriers for controlled release and encapsulation applications. In particular, the ability of these carriers to entrap both hydrophilic and hydrophobic drugs may be very promising for many applications. In addition, the absence of chemical compounds and organic solvents used to produce biopolymeric matrices could be very interesting for some industrial applications. Simple or complex coacervation methods involving proteins or protein and polysaccharide mixtures were used to create new matrices dedicated to controlled release applications. Controlled release experiments with model compounds were conducted in order to evaluate the performance of such matrices. An alternative and promising research field deals with particles obtained from hydrogel systems. Totally transparent solid matrices resulting from the dehydration of new protein gels were formed and swelling capacities of these matrices were studied.
生物聚合物是合成聚合物的一种有趣替代品，可用作控释和封装应用的结构化载体。特别是，这些载体捕获亲水和疏水药物的能力在许多应用中可能非常有前景。此外，用于生产生物聚合物基质的化合物和有机溶剂的缺失对于某些工业应用可能非常有吸引力。使用涉及蛋白质或蛋白质与多糖混合物的简单或复杂凝聚方法来创建专用于控释应用的新基质。对模型化合物进行控释实验以评估此类基质的性能。一个替代且有前景的研究领域涉及从水凝胶系统获得的颗粒。由新型蛋白质凝胶脱水形成的完全透明的固体基质，并研究了这些基质的溶胀能力。
