Jobmann Monika, Rafler Gerald
Fraunhofer-Institut für Angewandte Polymerforschung, Geiselbergstrasse 69, 14476, Golm, Germany.
Int J Pharm. 2002 Aug 21;242(1-2):213-7. doi: 10.1016/s0378-5173(02)00160-6.
The objective was to prepare small particles in the nm range with poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) applying the spontaneous emulsification process. Polymer parameters as well as process parameters were investigated. The results show that spontaneous emulsification is a simple method to produce small particles in the 200-1000 nm range. A major drawback is the limitation to very restricted conditions, e.g. molecular weight up to 30.000 g/mole, glycolide content in the copolymer up to 30 mole% and concentration of the polymer solution lower than or equal to 1% (w/v).
目的是通过自发乳化法，用聚（D，L-丙交酯）和聚（D，L-丙交酯-共-乙交酯）制备纳米级的小颗粒。研究了聚合物参数以及工艺参数。结果表明，自发乳化是一种制备200-1000nm范围内小颗粒的简单方法。一个主要缺点是该方法受非常严格条件的限制，例如分子量高达30000g/mol，共聚物中乙交酯含量高达30摩尔%，聚合物溶液浓度低于或等于1%（w/v）。
