Xinteng Z, Weisan P, Ruhua Z, Feng Z
Division of Pharmaceutics, Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Pharmazie. 2002 Oct;57(10):695-7.
PLA/PLGA was used for biodegradable and biocompatible carriers to achieve sustained release of estradiol. Microspheres were formed by an emulsification-solvent evaporation method, and then their properties and in vitro drug release behavior were examined including amongst others the effects of the concentration of PVA in the aqueous phase, the concentration of PLA in the organic phase, the stirring speed, the volume ratio of O/W, the weight ratio of E2/PLA fed, and the type and molecular weight of the polymers.
聚乳酸/聚乳酸-羟基乙酸共聚物被用作可生物降解且具有生物相容性的载体，以实现雌二醇的持续释放。通过乳化-溶剂蒸发法制备微球，然后研究其性质和体外药物释放行为，其中包括水相中聚乙烯醇浓度、有机相中聚乳酸浓度、搅拌速度、油/水体积比、进料时雌二醇与聚乳酸的重量比以及聚合物的类型和分子量等因素的影响。
