Aranow Cynthia, Del Guidice Jose, Barland Peter, Weinstein Arthur
Department of Medicine, New York Medical College, Valhalla, USA.
J Rheumatol. 2002 Aug;29(8):1674-7.
To assess the severity of systemic lupus erythematosus (SLE) in men compared to women.
A validated Lupus Severity of Disease Index (SDI) was used to assess disease severity in a retrospective multicenter case-control study. Each man (n = 18) was matched with 1-3 women (n = 36) for age, disease duration, and clinical setting. Clinical and serologic features were assessed and compared.
There was no significant sex difference in disease severity (SDI 4.8 men vs 3.9 women). Comparison of other clinical or serologic manifestations showed that cerebritis, thromboembolic phenomena, and antiphospholipid antibodies were more common in men.
There is no difference in lupus disease severity between men and women. However, there are sex-specific differences in expression of some disease manifestations.
评估男性与女性系统性红斑狼疮（SLE）的疾病严重程度。
在一项回顾性多中心病例对照研究中，使用经过验证的狼疮疾病严重指数（SDI）来评估疾病严重程度。将每位男性（n = 18）与1 - 3名女性（n = 36）按年龄、病程和临床情况进行匹配。对临床和血清学特征进行评估和比较。
疾病严重程度方面无显著性别差异（男性SDI为4.8，女性为3.9）。其他临床或血清学表现的比较显示，男性中脑炎、血栓栓塞现象和抗磷脂抗体更为常见。
男性和女性的狼疮疾病严重程度无差异。然而，某些疾病表现的表达存在性别特异性差异。
