Doran Michele F, Crowson Cynthia S, O'Fallon W Michael, Hunder Gene G, Gabriel Sherine E
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
J Rheumatol. 2002 Aug;29(8):1694-7.
To determine time trends in the incidence and survival of polymyalgia rheumatica (PMR) over a 30 year period in Olmsted County, Minnesota, USA.
Using the unified medical record linkage system of the Rochester Epidemiology Project, we identified all incident cases of PMR among residents of Olmsted County, MN, between January 1, 1970, and December 31, 1999. Incidence rates were estimated and age- and sex-adjusted to the 1990 US white population. The annual incidence rates were graphically illustrated using a 3 year centered moving average. A Poisson regression model was used to evaluate predictors of PMR incidence. Survival rates were computed and compared with the expected rates in the population.
There were 378 incident cases of PMR during the 30 year study period. Of these 66.6% were female and the mean age at incidence was 72.8 years. The overall age and sex adjusted annual incidence of PMR per 100,000 population aged > or = 50 years was 58.7 (95% CI 52.8,64.7). Incidence rates increased with age in both sexes, but in women, unlike in men, incidence fell after age 80. The incidence rates varied over the period of observation, but no significant trends over time were found. In the multivariable analysis, sex (p = 0.023), age (p < 0.001), and age2 (p < 0.001), but not calendar year (p = 0.24) were significant predictors of incidence. Survival among individuals with PMR was not significantly different from that expected in the population (p = 0.06).
The incidence of PMR has remained relatively stable over the past 30 years.
确定美国明尼苏达州奥姆斯特德县30年间风湿性多肌痛（PMR）的发病率及生存率变化趋势。
利用罗切斯特流行病学项目的统一医疗记录链接系统，我们确定了1970年1月1日至1999年12月31日期间明尼苏达州奥姆斯特德县居民中所有PMR的发病病例。估算发病率，并根据1990年美国白人人口进行年龄和性别调整。使用3年中心移动平均值以图形方式展示年发病率。采用泊松回归模型评估PMR发病率的预测因素。计算生存率并与人群中的预期生存率进行比较。
在30年的研究期间，共有378例PMR发病病例。其中66.6%为女性，发病时的平均年龄为72.8岁。每10万年龄≥50岁人群中，经年龄和性别调整后的PMR总体年发病率为58.7（95%置信区间52.8,64.7）。男女发病率均随年龄增加，但与男性不同，女性在80岁后发病率下降。发病率在观察期内有所变化，但未发现随时间的显著趋势。在多变量分析中，性别（p = 0.023）、年龄（p < 0.001）和年龄平方（p < 0.001）是发病率的显著预测因素，而日历年（p = 0.24）不是。PMR患者的生存率与人群预期生存率无显著差异（p = 0.06）。
在过去30年中，PMR的发病率一直相对稳定。
