Gran J T, Myklebust G
Department of Rheumatology, Regional hospital of Tromsø, Norway.
J Rheumatol. 1997 Sep;24(9):1739-43.
To determine the incidence of giant cell arteritis (GCA) including polymyalgia rheumatica (PMR) and temporal arteritis (TA) in a region of South Norway.
All physicians in the county were asked to refer all patients suspected of having PMR or TA to the Department of Rheumatology. Patients meeting diagnostic criteria and with disease onset during 1987-94 were included in a prospective study. In addition, all cases admitted to hospital departments other than rheumatology were evaluated retrospectively.
In total, 322 patients with PMR or TA were found. The annual incidence of GCA per 100,000 population aged 50 years or more was 141.7, 177.6 in women and 99.5 in men. Pure PMR was found in 256 cases, while 66 patients had biopsy verified TA. The annual incidence of pure PMR per 100,000 residents aged 50 years or more was 112.6, 137.7 in women and 83.2 in men. The annual incidence of TA in persons 50 years and older was 29.0 per 100,000, 39.9 in women and 16.3 in men.
The high incidence of GCA we found was due to excess of cases with pure PMR. The high number of cases with PMR was most likely due to the design of the study, allowing inclusion of patients usually not detected by retrospective hospital based studies.
确定挪威南部某地区巨细胞动脉炎(GCA)(包括风湿性多肌痛(PMR)和颞动脉炎(TA))的发病率。
要求该郡所有医生将所有疑似患有PMR或TA的患者转诊至风湿病科。符合诊断标准且在1987 - 1994年期间发病的患者纳入一项前瞻性研究。此外,对除风湿病科以外的其他医院科室收治的所有病例进行回顾性评估。
共发现322例PMR或TA患者。每10万50岁及以上人群中GCA的年发病率为141.7,女性为177.6,男性为99.5。发现256例为单纯PMR,66例经活检证实为TA。每10万50岁及以上居民中单纯PMR的年发病率为112.6,女性为137.7,男性为83.2。50岁及以上人群中TA的年发病率为每10万29.0,女性为39.9,男性为16.3。
我们发现的GCA高发病率是由于单纯PMR病例过多。PMR病例数量多很可能是由于研究设计,使得通常在基于医院回顾性研究中未被检测到的患者得以纳入。