[软骨组织工程的潜在种子细胞——骨髓基质干细胞]
[Potential seeding cells for cartilage tissue engineering--bone marrow stromal stem cells].
作者信息
Kong Qing-quan, Xiang Zhou, Yang Zhi-ming
机构信息
Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China 610041.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2002 Jul;16(4):277-80.
OBJECTIVE
To review the recent research progress of bone-marrow stromal stem cells (BMSCs) in the conditions of culture in vitro, chondrogenic differentiation, and the application in cartilage tissue engineering.
METHODS
Recent original articles related to such aspects of BMSCs were reviewed extensively.
RESULTS
BMSCs are easy to be isolated and cultivated. In the process of chondrogenesis of BMSCs, the special factors and interaction between cells are investigated extensively. BMSCs have been identified to form cartilage in vivo. One theory is the committed chondrocyte from BMSCs is only a transient stage.
CONCLUSION
BMSCs are the alternative seeding cells for cartilage tissue engineering. The conditions promoting mature chondrocyte should be further investigated.
目的
综述骨髓间充质干细胞（BMSCs）在体外培养、软骨分化条件及软骨组织工程应用方面的最新研究进展。
方法
广泛回顾了与BMSCs这些方面相关的近期原创文章。
结果
BMSCs易于分离和培养。在BMSCs软骨形成过程中，对特定因子及细胞间相互作用进行了广泛研究。已证实BMSCs在体内可形成软骨。一种理论认为，BMSCs来源的定向软骨细胞只是一个过渡阶段。
结论
BMSCs是软骨组织工程的替代种子细胞。促进成熟软骨细胞形成的条件有待进一步研究。
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