骨髓间充质干细胞作为组织工程软骨种子细胞的研究进展
[Recent progress of BMSCs acting as seeding cell for tissue engineered cartilage].
作者信息
Xu Shuqia, Xu Yangbin
机构信息
Department of Plastic Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou Guangdong, 510080, P.R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008 Feb;22(2):163-6.
OBJECTIVE
To review the recent progress of BMSCs acting as seeding cell for tissue engineered cartilage.
METHODS
The recent ten years literature about BMSCs acting as seeding cell for tissue engineered cartilage was extensively reviewed.
RESULTS
Scaffold provided an optimal environment for the growth of BMSCs. Cytokine and gene delivery could promote BMSCs to differentiate toward chondrocytes. All of them played important roles in the field of cartilage tissue engineering.
CONCLUSION
The improvement of three-dimensional scaffolds, the rational use of cytokine, and the enhancement of gene delivery will promote the development of clinical cartilage reconstruction.
目的
综述骨髓间充质干细胞作为组织工程软骨种子细胞的研究进展。
方法
广泛查阅近十年有关骨髓间充质干细胞作为组织工程软骨种子细胞的文献。
结果
支架为骨髓间充质干细胞的生长提供了适宜环境。细胞因子和基因递送可促进骨髓间充质干细胞向软骨细胞分化。它们在软骨组织工程领域均发挥着重要作用。
结论
三维支架的改进、细胞因子的合理应用以及基因递送的增强将推动临床软骨重建的发展。
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