Brola Waldemar, Wegrzyn Waldemar, Czernicki Jan
Oddziału Neurologii Szpitala Sw. łukasza w Końskich.
Wiad Lek. 2002;55(3-4):136-43.
Modern treatment of multiple sclerosis (SM) takes into consideration the current stage of the disease, symptomatic treatment and modification of the course of the disease. The most promising method of management is immunotherapy. It is, however, effective only in some cases, in patients with low degree of disability, and it is rather expensive. In view of some recent reports concerning the possibility of utilisation of variable magnetic fields in the treatment of SM, the study was undertaken to evaluate the effectiveness of impulses generated by magnetic field obtained by means of VIOFOR JPS stimulator. The study was carried out on 76 subjects with long-term history of clinically confirmed SM. The mean duration of the disease was 8.5 years, and the mean age of the patients 37.8 years. The patients were divided into two groups: the study group and the controls. In the study group the patients were exposed to magnetic fields generated by VIOFOR JPS. Magnetic stimulation was not applied in the control group. The progress of the disease according to EDDS and the quality of life according to Testa and Simonson Questionnaire were assessed on admission and after 21 days of stimulation. No significant differences between the groups were found with respect to motor impairment evaluated using the EDDS score (6.2 at the beginning of the study and 5.1 after 21 days; in the control group--6.1 and 5.6, respectively). The quality of life was found to be significantly better in the group exposed to magnetic field stimulation than in the controls (p < 0.01). Particular variables contributing to the physical, psychological and social component of quality of life were analysed in detail. The most significant difference was observed with respect to the improvement of mental condition of the patients (alleviation of depression, elimination of anxiety, better emotional control), as well as to the decrease of muscle tone, dysaesthesia and painful sensations. No side effects were observed in any of the cases. The obtained effects encourage us to recommend magnetic stimulation as a method supplementing symptomatic treatment of patients with multiple sclerosis.
多发性硬化症（SM）的现代治疗需考虑疾病的当前阶段、对症治疗以及病程的改变。最有前景的治疗方法是免疫疗法。然而，它仅在某些情况下对残疾程度较低的患者有效，而且费用相当高。鉴于最近一些关于在SM治疗中使用可变磁场可能性的报告，开展了本研究以评估通过VIOFOR JPS刺激器获得的磁场产生的脉冲的有效性。该研究针对76名有临床确诊SM长期病史的受试者进行。疾病的平均持续时间为8.5年，患者的平均年龄为37.8岁。患者被分为两组：研究组和对照组。研究组的患者接受VIOFOR JPS产生的磁场。对照组未进行磁刺激。在入院时和刺激21天后，根据扩展残疾状态量表（EDSS）评估疾病进展，并根据Testa和Simonson问卷评估生活质量。使用EDSS评分评估运动障碍时，两组之间未发现显著差异（研究开始时为6.2，21天后为5.1；对照组分别为6.1和5.6）。发现接受磁场刺激的组的生活质量明显优于对照组（p < 0.01）。详细分析了对生活质量的身体、心理和社会组成部分有贡献的特定变量。在患者精神状态的改善（减轻抑郁、消除焦虑、更好的情绪控制）以及肌肉张力、感觉异常和疼痛感觉的降低方面观察到最显著的差异。在任何病例中均未观察到副作用。所获得的结果促使我们推荐磁刺激作为多发性硬化症患者对症治疗的一种补充方法。
