Lawlor Debbie A, Davey Smith George, Ebrahim Shah
Department of Social Medicine, University of Bristol, Bristol BS8 2PR.
BMJ. 2002 Aug 17;325(7360):359. doi: 10.1136/bmj.325.7360.359.
To investigate the association between birth weight of offspring and mothers' insulin resistance in late adulthood.
Cross sectional survey.
General practitioner's surgeries in 23 towns in Great Britain.
4286 women aged 60-79 years.
Maternal insulin resistance.
Birth weight of offspring was inversely related to maternal insulin resistance in late adulthood. For each 1 kg higher birth weight of offspring, women had a 15% reduction in the odds of being in the fourth with highest insulin resistance, compared to other fourths (odds ratio 0.85; 95% confidence interval 0.71 to 1.00). This increased to 27% (0.73; 0.60 to 0.90) after adjusting data for potential confounders. A U shaped relation between birth weight of offspring and diabetes in older age was found; women with the lightest and heaviest offspring had the highest prevalence of diabetes.
Birth weight of offspring is inversely related to the mother's insulin resistance in late adulthood, despite the association of glucose intolerance during pregnancy with heavier offspring at birth. Common genetic factors contribute to the relation between birth weight and risk of cardiovascular disease and diabetes in adults.
研究成年后期子代出生体重与母亲胰岛素抵抗之间的关联。
横断面调查。
英国23个城镇的全科医生诊所。
4286名年龄在60 - 79岁之间的女性。
母亲的胰岛素抵抗。
成年后期子代出生体重与母亲胰岛素抵抗呈负相关。子代出生体重每增加1千克，与其他四分位数相比，女性处于胰岛素抵抗最高的第四个四分位数的几率降低15%（优势比0.85；95%置信区间0.71至1.00）。在对潜在混杂因素进行数据调整后，这一比例增至27%（0.73；0.60至0.90）。研究发现子代出生体重与老年糖尿病之间呈U形关系；子代体重最轻和最重的女性糖尿病患病率最高。
尽管孕期糖耐量异常与出生时较重的子代有关，但成年后期子代出生体重与母亲的胰岛素抵抗呈负相关。常见的遗传因素促成了出生体重与成年人心血管疾病和糖尿病风险之间的关系。
