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出生体重、心血管健康与心血管疾病风险：来自英国生物银行队列的纵向研究视角

Birth weight, cardiovascular health, and the risk of cardiovascular disease: A longitudinal perspective from the UK biobank cohort.

作者信息

Long Jinping, Feng Anping, Cui Qingmei, Liu Zhilin, Chen Shiqun, Chen Siqi, Zhang Miaomiao, Zheng Danlin, Huang Hailan, An Ran, Zou Xia

机构信息

Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Global Health Research Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

出版信息

Am J Prev Cardiol. 2025 Aug 22;23:101273. doi: 10.1016/j.ajpc.2025.101273. eCollection 2025 Sep.

DOI:10.1016/j.ajpc.2025.101273

PMID:40918930

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12410404/

Abstract

BACKGROUND

The associations between birth weight (BW), cardiovascular health (CVH) as assessed by Life's Essential 8 (LE8) and cardiovascular diseases (CVDs) remain unclear. We aimed to assess the independent and joint associations of BW and CVH with risks of CVDs.

METHODS

This study included 143,910 UK Biobank participants without CVD at baseline (2006-2010). BW was self-reported, and CVH was evaluated using the LE8 score. Cox models were employed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident total CVD and nine cardiovascular conditions.

RESULTS

During a median 15.1-year follow-up, 24,071 CVD cases occurred. Compared with normal BW (2.5-4.0 kg), low BW was associated with increased risks of total CVD (adjusted HR [aHR]: 1.13, 95% CI [1.08 to 1.17], < 0.001), CVD death (aHR: 1.25 [1.11 to 1.40]), and six other CVDs (aHR ranging from 1.09 to 1.36). High BW was associated with higher risks of aortic aneurysom (aHR: 1.20 [1.03 to 1.39], = 0.02) and dysrhythmias (aHR: 1.08 [1.03 to 1.14], = 0.003), but lower risks of peripheral artery disease (aHR: 0.78 [0.67 to 0.91], = 0.002) and ischemic heart disease (aHR: 0.94 [0.89 to 1.00, = 0.05). Compared with low LE8 score, high LE8 score was associated with 55%-60% lower risk of total CVD in participants with various BW, and no interactions were found.

CONCLUSIONS

Low BW was associated with an increased risk of CVD, whereas high BW showed a neutral association. High CVH, as evaluated by LE8, was associated with a reduced incidence of CVD irrespective of BW.

摘要

背景

出生体重（BW）、通过生命八大要素（LE8）评估的心血管健康（CVH）与心血管疾病（CVD）之间的关联尚不清楚。我们旨在评估BW和CVH与CVD风险的独立及联合关联。

方法

本研究纳入了143,910名英国生物银行的参与者，他们在基线时（2006 - 2010年）无CVD。BW为自我报告，CVH使用LE8评分进行评估。采用Cox模型估计总CVD及九种心血管疾病的发病风险比（HRs）和95%置信区间（CIs）。

结果

在中位15.1年的随访期间，发生了24,071例CVD病例。与正常BW（2.5 - 4.0千克）相比，低BW与总CVD风险增加相关（校正HR [aHR]：1.13，95% CI [1.08至1.17]，<0.001）、CVD死亡风险增加（aHR：1.25 [1.11至1.40]）以及其他六种CVD风险增加（aHR范围为1.09至1.36）。高BW与主动脉瘤风险增加相关（aHR：1.20 [1.03至1.39]，=0.02）和心律失常风险增加（aHR：1.08 [1.03至1.14]，=0.003），但外周动脉疾病风险降低（aHR：0.78 [0.67至0.91]，=0.002）和缺血性心脏病风险降低（aHR：0.94 [0.89至1.00，=0.05]）。与低LE8评分相比，高LE8评分与不同BW参与者的总CVD风险降低55% - 60%相关，且未发现相互作用。