Klasse P J, Sattentau Q J
Jefferiss Research Trust Laboratories, Wright-Fleming Institute, Imperial College of Science, Technology and Medicine, St Mary's Campus, Norfolk Place, London W2 1PG, UK1.
J Gen Virol. 2002 Sep;83(Pt 9):2091-2108. doi: 10.1099/0022-1317-83-9-2091.
Neutralization of virus infectivity by antibodies is an important component of immunity to several virus infections. Here, the immunochemical basis for the action of neutralizing antibodies, and what role their induction of conformational changes in the antigen might play, is reviewed. Theories of the mechanisms by which antibodies neutralize virus infectivity in vitro are also presented. The theoretical and empirical foundation of the hypothesis that viruses are neutralized by a single antibody per virion is critically reviewed. The relationship between antibody occupancy on virions and the mechanism of neutralization is explored. Examples of neutralization mediated through antibody interference with virus attachment and entry are discussed and test implications of refined theories of neutralization by antibody coating of virions are formulated.
抗体对病毒感染性的中和作用是针对多种病毒感染的免疫的重要组成部分。在此，对中和抗体作用的免疫化学基础以及它们诱导抗原构象变化可能发挥的作用进行综述。还介绍了抗体在体外中和病毒感染性的机制理论。对每个病毒粒子由单一抗体中和病毒这一假说的理论和实证基础进行了批判性综述。探讨了病毒粒子上抗体占据情况与中和机制之间的关系。讨论了通过抗体干扰病毒附着和进入介导的中和实例，并阐述了通过病毒粒子抗体包被的中和精细理论的测试意义。
