Weigel Stefan, Kuhlmann Jan, Hühnerfuss Heinrich
Institute of Organic Chemistry, University of Hamburg, Germany.
Sci Total Environ. 2002 Aug 5;295(1-3):131-41. doi: 10.1016/s0048-9697(02)00064-5.
An analytical method is presented, which allows the simultaneous extraction of neutral and acidic compounds from 20-L seawater samples at ambient pH (approximately 8.3). It is based on a solid-phase extraction by means of a polystyrene-divinylbenzene sorbent and gas chromatographic-mass spectrometric detection, and provides detection limits in the lower pg/L range. The method was applied to the screening of samples from different North Sea areas for clofibric acid, diclofenac, ibuprofen, ketoprofen, propyphenazone, caffeine and N,N-diethyl-3-toluamide (DEET). Whereas clofibric acid, caffeine and DEET showed to be present throughout the North Sea in concentrations of up to 1.3, 16 and 1.1 ng/L, respectively, propyphenazone could only be detected after further clean-up. Diclofenac and ibuprofen were found in the estuary of the river Elbe (6.2 and 0.6 ng/L, respectively) but in none of the marine samples. Ketoprofen was below the detection limit in all samples.
本文介绍了一种分析方法，该方法可在环境pH值（约8.3）下从20升海水样品中同时提取中性和酸性化合物。它基于聚苯乙烯-二乙烯基苯吸附剂的固相萃取和气相色谱-质谱检测，检测限低至pg/L范围。该方法用于筛查北海不同区域的样品中的氯贝酸、双氯芬酸、布洛芬、酮洛芬、保泰松、咖啡因和N,N-二乙基-3-甲苯酰胺（避蚊胺）。氯贝酸、咖啡因和避蚊胺在北海各地均有检出，浓度分别高达1.3、16和1.1 ng/L，而保泰松只有在进一步净化后才能检测到。在易北河河口发现了双氯芬酸和布洛芬（分别为6.2和0.6 ng/L），但在所有海洋样品中均未发现。所有样品中的酮洛芬均低于检测限。
