腹主动脉瘤中血流诱导的壁面剪应力：第一部分——稳定流动血液动力学

Flow-induced wall shear stress in abdominal aortic aneurysms: Part I--steady flow hemodynamics.

作者信息

Finol Ender A, Amon Cristina H

机构信息

Mechanical Engineering, Biomedical and Health Engineering, and institute for Complex Engineered Systems, Carnegie Mellon University, Pittsburgh, PA, USA.

出版信息

Comput Methods Biomech Biomed Engin. 2002 Aug;5(4):309-18. doi: 10.1080/1025584021000009742.

DOI:10.1080/1025584021000009742

PMID:12186710

Abstract

Numerical predictions of blood flow patterns and hemodynamic stresses in Abdominal Aortic Aneurysms (AAAs) are performed in a two-aneurysm, axisymmetric, rigid wall model using the spectral element method. Homogeneous, Newtonian blood flow is simulated under steady conditions for the range of Reynolds numbers 10 < or =Re < or =2265. Flow hemodynamics are quantified by calculating the distributions of wall pressure (p(w)), wall shear stress (tau(w)), Wall Shear Stress Gradient (WSSG). A correlation between maximum values of hemodynamic stresses and Reynolds number is established, and the spatial distribution of WSSG is considered as a hemodynamic force that may cause damage to the arterial wall at an intermediate stage of AAA growth. The temporal distribution of hemodynamic stresses in pulsatile flow and their physical implications in AAA rupture are discussed in Part II of this paper.

摘要

使用谱元法在一个双动脉瘤、轴对称、刚性壁模型中对腹主动脉瘤（AAA）内的血流模式和血流动力学应力进行了数值预测。在雷诺数范围为10≤Re≤2265的稳定条件下模拟了均匀的牛顿血流。通过计算壁面压力（p(w)）、壁面剪应力（tau(w)）、壁面剪应力梯度（WSSG）的分布来量化血流动力学。建立了血流动力学应力最大值与雷诺数之间的相关性，并将WSSG的空间分布视为在AAA生长中期可能导致动脉壁损伤的血流动力学力。本文第二部分讨论了脉动流中血流动力学应力的时间分布及其在AAA破裂中的物理意义。