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腹主动脉瘤中的血流:脉动血流动力学

Blood flow in abdominal aortic aneurysms: pulsatile flow hemodynamics.

作者信息

Finol E A, Amon C H

机构信息

Mechanical Engineering, Biomedical and Health Engineering, and Institute for Complex Engineered Systems, Carnegie Mellon University, Pittsburgh, PA 15213-3890, USA.

出版信息

J Biomech Eng. 2001 Oct;123(5):474-84. doi: 10.1115/1.1395573.

Abstract

Numerical predictions of blood flow patterns and hemodynamic stresses in Abdominal Aortic Aneurysms (AAAs) are performed in a two-aneurysm, axisymmetric, rigid wall model using the spectral element method. Physiologically realistic aortic blood flow is simulated under pulsatile conditions for the range of time-averaged Reynolds numbers 50< or =Re(m)< or =300, corresponding to a range of peak Reynolds numbers 262.5< or =Re(peak) < or = 1575. The vortex dynamics induced by pulsatile flow in AAAs is characterized by a sequence of five different flow phases in one period of the flow cycle. Hemodynamic disturbance is evaluated for a modified set of indicator functions, which include wall pressure (p(w)), wall shear stress (tau(w)), and Wall Shear Stress Gradient (WSSG). At peak flow, the highest shear stress and WSSG levels are obtained downstream of both aneurysms, in a pattern similar to that of steady flow. Maximum values of wall shear stresses and wall shear stress gradients obtained at peak flow are evaluated as a function of the time-average Reynolds number resulting in a fourth order polynomial correlation. A comparison between predictions for steady and pulsatile flow is presented, illustrating the importance of considering time-dependent flow for the evaluation of hemodynamic indicators.

摘要

使用谱元法在一个双动脉瘤轴对称刚性壁模型中对腹主动脉瘤(AAA)内的血流模式和血流动力学应力进行数值预测。在脉动条件下,针对时间平均雷诺数50≤Re(m)≤300的范围模拟生理上逼真的主动脉血流,该范围对应于峰值雷诺数262.5≤Re(peak)≤1575。AAA中脉动流诱导的涡旋动力学在流动周期的一个周期内由五个不同的流动阶段序列表征。针对一组改进的指标函数评估血流动力学扰动,这些指标函数包括壁面压力(p(w))、壁面剪应力(tau(w))和壁面剪应力梯度(WSSG)。在峰值流量时,在两个动脉瘤下游获得最高剪应力和WSSG水平,其模式类似于稳定流。将峰值流量时获得的壁面剪应力和壁面剪应力梯度的最大值作为时间平均雷诺数的函数进行评估,得到一个四阶多项式相关性。给出了稳定流和脉动流预测之间的比较,说明了在评估血流动力学指标时考虑时间相关流的重要性。

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