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模仿人类主动脉瘤的实验动物模型开发的最新进展

Recent Advances in the Development of Experimental Animal Models Mimicking Human Aortic Aneurysms.

作者信息

Yoo Young Sun, Park Hyung Sub, Choi Geum Hee, Lee Taeseung

机构信息

Department of Surgery, Chosun University Hospital, Chosun University College of Medicine, Gwangju.

Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam.

出版信息

Vasc Specialist Int. 2015 Mar;31(1):1-10. doi: 10.5758/vsi.2015.31.1.1. Epub 2015 Mar 31.

DOI:10.5758/vsi.2015.31.1.1
PMID:26217637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4480291/
Abstract

Aortic aneurysm is a common and life-threatening disease that can cause death from rupture. Current therapeutic options are limited to surgical or endovascular procedures because no pharmacological approaches have been proven to decrease the chance of expansion or rupture. The best approach to the management of aortic aneurysm would be the understanding and prevention of the processes involved in disease occurrence, progression, and rupture. There is a need for animal models that can reproduce the pathophysiological features of human aortic aneurysm, and several such models have been studied. This review will emphasize recent advances in animal models used in the determination of mechanisms and treatments of aortic aneurysms.

摘要

主动脉瘤是一种常见且危及生命的疾病，可因破裂导致死亡。目前的治疗选择仅限于外科手术或血管内介入手术，因为尚无药理学方法被证明能降低扩张或破裂的几率。主动脉瘤管理的最佳方法是了解和预防疾病发生、发展及破裂过程中涉及的机制。需要能够重现人类主动脉瘤病理生理特征的动物模型，并且已经对几种此类模型进行了研究。本综述将重点介绍用于确定主动脉瘤发病机制和治疗方法的动物模型的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/a1ec234c326f/vsi-31-01f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/7f2bc3c06987/vsi-31-01f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/ce9cbadcf394/vsi-31-01f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/227873732b5b/vsi-31-01f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/e108f05ae5d4/vsi-31-01f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/d680e4a4a3a2/vsi-31-01f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/a1ec234c326f/vsi-31-01f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/7f2bc3c06987/vsi-31-01f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/ce9cbadcf394/vsi-31-01f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/227873732b5b/vsi-31-01f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/e108f05ae5d4/vsi-31-01f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/d680e4a4a3a2/vsi-31-01f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3f/4480291/a1ec234c326f/vsi-31-01f6.jpg

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J Surg Res. 2013 Nov;185(1):455-62. doi: 10.1016/j.jss.2013.05.002. Epub 2013 May 23.
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Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt.盐皮质激素受体激动剂在高盐存在的情况下可诱导小鼠主动脉瘤的形成和破裂。
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Potential role of vascular smooth muscle cell-like progenitor cell therapy in the suppression of experimental abdominal aortic aneurysms.
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Performance of a modified rabbit model of abdominal aortic aneurysm induced by topical application of porcine elastase: 5-month follow-up study.经猪弹性蛋白酶局部应用诱导的改良兔腹主动脉瘤模型的性能：5 个月随访研究。
Eur J Vasc Endovasc Surg. 2013 Feb;45(2):145-52. doi: 10.1016/j.ejvs.2012.11.015. Epub 2012 Dec 29.
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