Müller Sandra V, Jung Andrea, Preinfalk Jens, Kolbe Hans, Ridao-Alonso Maria, Dengler Reinhard, Münte Thomas F
Department of Neuropsychology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
J Clin Exp Neuropsychol. 2002 Jun;24(4):517-26. doi: 10.1076/jcen.24.4.517.1043.
Neuropsychological deficits are a main feature of Huntington's disease (HD) with previous data suggesting involvement of attentional functions. Attention can be divided into several different dimensions: intensity, selectivity and supervisory attentional control. These different aspects of attention were investigated in a group of 13 patients with HD and 13 healthy matched control subjects. HD patients were impaired mostly for the intensity dimension: contrary to controls, and like other neurological patient groups, they were not able to speed up their reaction times when an auditory warning stimulus preceded a visual target which suggests a deficit in 'extrinsic alertness.' In addition less severe impairments were found in the dimensions selectivity and supervisory attentional control.
神经心理学缺陷是亨廷顿舞蹈症（HD）的主要特征，先前的数据表明其涉及注意力功能。注意力可分为几个不同维度：强度、选择性和监督性注意力控制。在一组13名HD患者和13名健康对照受试者中对注意力的这些不同方面进行了研究。HD患者在强度维度上大多受损：与对照组相反，和其他神经疾病患者群体一样，当听觉警告刺激先于视觉目标出现时，他们无法加快反应时间，这表明存在“外在警觉性”缺陷。此外，在选择性和监督性注意力控制维度上发现了不太严重的损伤。
