Moberg P J, Pearlson G D, Speedie L J, Lipsey J R, Strauss M E, Folstein S E
Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21205.
J Clin Exp Neuropsychol. 1987 Dec;9(6):650-64. doi: 10.1080/01688638708405208.
Forty-two patients with senile dementia of the Alzheimer type (SDAT), 38 patients with Huntington's disease (HD) and matched normal controls were administered tests of olfactory, verbal, and visual recognition after being screened for normal olfactory discrimination. Early-affected Huntington's patients (EHD) with minimal chorea or cognitive deficit displayed marked deficits in olfactory recognition despite normal verbal and visual performance, even after correction for task difficulty, suggesting involvement of olfactory brain regions early in the disease process. In the early Alzheimer's group (EAD), marked deficits were seen on all recognition modalities indicating more global impairment. Both overall (early plus late) patient groups were impaired relative to controls on all recognition tasks, with the olfactory paradigm being most affected.
对42例阿尔茨海默型老年痴呆症（SDAT）患者、38例亨廷顿舞蹈症（HD）患者以及相匹配的正常对照者进行嗅觉、语言和视觉识别测试，测试前已筛查其嗅觉辨别能力正常。早期受影响的亨廷顿舞蹈症患者（EHD），舞蹈症或认知缺陷轻微，尽管语言和视觉表现正常，但嗅觉识别仍有明显缺陷，即使校正任务难度后仍是如此，这表明在疾病过程早期嗅觉脑区就已受累。在早期阿尔茨海默病组（EAD）中，所有识别方式均有明显缺陷，表明损伤更为广泛。相对于对照组，两个总体（早期加晚期）患者组在所有识别任务中均受损，其中嗅觉范式受影响最大。
