Abnormal P300 in a case of delusional misidentification with coinciding Capgras and Frégoli symptoms.

The Delusional Misidentification Syndrome (DMS) is thought to be related to dissociation between recognition and identification processes. Working memory (WM) is considered responsible for the integration and online manipulation of information, so that it is available for further processing. Since the P300 component of event-related potentials (ERPs) is considered as an index of the on-line updating of WM, the present study is focused on auditory P300 elicited during a WM test in DMS, compared with that in healthy controls. ERPs, elicited during a WM test, in a case suffering from coinciding Capgras and Frégoli symptoms, were recorded. Peak amplitude and latency of the averaged P300 waveforms, as well as memory performance of this case, were compared to the patterns obtained from healthy controls. In relation to normal controls, the patient exhibited significantly attenuated amplitude of P300 at the F4, P3 and Pz abductions. The patient also showed significantly prolonged latencies of P300 at all abductions used. These findings suggest that DMS may be accompanied by WM dysfunction affecting brain regions outside the prefrontal cortex, as well as within, and by diffuse failure to allocate attention resources to a stimulus, as they are reflected by P300 amplitudes and latencies respectively. Additionally, it may be suggested that techniques designed to explore cognitive operations, such as recording of ERPs, and more specifically P300, during WM tasks, could provide further insights into the relationship between neural functioning and the cognitive deficits in DMS.